Publications
Publications
Malecka, J., Tonelli, E., Saverio, V., Zanetta, P., Dematteis, G., Tapella, L., & Lim, D. (2025). ER-mitochondria contacts: a bridge to healthy ageing? Ageing & Longevity, 3.2025, 199–211. Internet Archive. https://doi.org/10.47855/jal9020-2025-3-4
Dematteis G, Gong C, Malecka J, Tonelli E, Genazzani A, Tapella L, Eleuteri AM, Lim D, Bonfili L. Rescue of protein dyshomeostasis in hippocampal astrocytes from an Alzheimer's disease mouse model by stabilizing ER-mitochondrial interactions at a 20 nm distance. Alzheimers Res Ther. 2025 Jul 4;17(1):148. doi: 10.1186/s13195-025-01793-9. PMID: 40615914; PMCID: PMC12228274.
Dematteis G, Lecchi G, Boni G, Pendin D, Distasi C, Grilli M, Lim D, Fresu LG, Talmon M. ATM knock out alters calcium signalling and augments contraction in skeletal muscle cells differentiated from human urine-derived stem cells. Cell Death Discov. 2025 Apr 15;11(1):177. doi: 10.1038/s41420-025-02485-x. PMID: 40234386; PMCID: PMC12000312.
Monzani R, Gagliardi M, Saverio V, Clemente N, Monzani A, Rabbone I, Nigrelli F, Pellizzaro S, Ferrario E, Saettone S, Pagano N, De Leo L, Lim D, Sblattero D, Corazzari M. The CXCR3/PLC/IP3-IP3R axis is responsible for the ignition of UPR in intestinal epithelial cells exposed to gliadin peptide, during the onset of celiac disease. Biol Direct. 2025 Mar 31;20(1):39. doi: 10.1186/s13062-025-00633-y. PMID: 40165272; PMCID: PMC11956425.
Monzani R, Gagliardi M, Saverio V, Clemente N, Monzani A, Rabbone I, Nigrelli F, Pellizzaro S, Ferrario E, Saettone S, Pagano N, De Leo L, Lim D, Sblattero D, Corazzari M. Gliadin-dependent UPR induction directly triggers the expression of TG2 and pro-inflammatory cytokines, dysregulates intestinal permeability, and reduces CFTR expression in intestinal epithelial cells of celiac disease patients. Biol Direct. 2025 Apr 17;20(1):55. doi: 10.1186/s13062-025-00644-9. PMID: 40247380; PMCID: PMC12007252.
Yamaguchi I, Barazzuol L, Dematteis G, Zhu W, Wen Y, Drobizhev M, Lim D, Campbell RE, Calì T, Nasu Y. Bipartite Genetically Encoded Biosensors to Sense Calcium Ion Dynamics at Membrane-Membrane Contact Sites. Anal Chem. 2025 Sep 16;97(36):19848-19861. doi: 10.1021/acs.analchem.5c03831. Epub 2025 Sep 1. PMID: 40888292; PMCID: PMC12444748.
Delconti M, Ravasenga T, Dionisi M, Romanazzi T, Chiazza F, Giatti S, Lim D, Genazzani AA, Riva B, Meregalli C, Cavaletti G, Distasi C. Paclitaxel activates SOCE/ICRAC in dorsal root ganglion neurons: implications for paclitaxel-induced peripheral neuropathy. Cell Calcium. 2025 Sep;130:103040. doi: 10.1016/j.ceca.2025.103040. Epub 2025 May 27. PMID: 40460736.
Lim D, Matute C, Cavaliere F, Verkhratsky A. Neuroglia in neurodegeneration: Alzheimer, Parkinson, and Huntington disease. Handb Clin Neurol. 2025;210:9-44. doi: 10.1016/B978-0-443-19102-2.00012-0. PMID: 40148060.
Tonelli E, Malecka J, Barberis E, Romano C, Pessolano E, Talmon M, Genazzani AA, Casali C, Biggiogera M, Manfredi M, Tapella L, Lim D, Dematteis G. Remodelling of Cellular Protein Homeostasis by Enhanced ER-Mitochondrial Tethering. Contact (Thousand Oaks). 2025 Apr 1;8:25152564251329704. doi: 10.1177/25152564251329704. PMID: 40177215; PMCID: PMC11963730.
Dematteis G, Tapella L, Casali C, Talmon M, Tonelli E, Reano S, Ariotti A, Pessolano E, Malecka J, Chrostek G, Kulkovienė G, Umbrasas D, Distasi C, Grilli M, Ladds G, Filigheddu N, Fresu LG, Mikoshiba K, Matute C, Ramos-Gonzalez P, Jekabsone A, Calì T, Brini M, Biggiogera M, Cavaliere F, Miggiano R, Genazzani AA, Lim D. ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca2+ uptake and oxidative metabolism. Commun Biol. 2024 Oct 10;7(1):1294. doi: 10.1038/s42003-024-06933-9. PMID: 39390051; PMCID: PMC11467464.
Dematteis G, Tapella L, Lim D. Probing the endoplasmic reticulum-mitochondria interaction in Alzheimer's disease: searching far and wide. Neural Regen Res. 2024 Oct 1;19(10):2103-2104. doi: 10.4103/1673-5374.392880. Epub 2024 Jan 8. PMID: 38488539; PMCID: PMC11034600.
Pinton G, Perucca M, Gigliotti V, Mantovani E, Clemente N, Malecka J, Chrostek G, Dematteis G, Lim D, Moro L, Chiazza F. EZH2-Mediated H3K27 Trimethylation in the Liver of Mice Is an Early Epigenetic Event Induced by High-Fat Diet Exposure. Nutrients. 2024 Sep 26;16(19):3260. doi: 10.3390/nu16193260. PMID: 39408226; PMCID: PMC11479199.
Lim D, Verkhratsky A. Alterations of protein homeostasis in Alzheimer's disease: beyond Procrustean bed of endoplasmic reticulum stress and unfolded protein response. Neural Regen Res. 2024 Aug 1;19(8):1645-1646. doi: 10.4103/1673-5374.389642. Epub 2023 Dec 11. PMID: 38103222; PMCID: PMC10960295.
Romagnolo A, Dematteis G, Scheper M, Luinenburg MJ, Mühlebner A, Van Hecke W, Manfredi M, De Giorgis V, Reano S, Filigheddu N, Bortolotto V, Tapella L, Anink JJ, François L, Dedeurwaerdere S, Mills JD, Genazzani AA, Lim D, Aronica E. Astroglial calcium signaling and homeostasis in tuberous sclerosis complex. Acta Neuropathol. 2024 Feb 28;147(1):48. doi: 10.1007/s00401-024-02711-3. PMID: 38418708; PMCID: PMC10901927.
Tapella L, Dematteis G, La Vitola P, Leva S, Tonelli E, Raddi M, Delconti M, Dacomo L, La Macchia A, Murari E, Talmon M, Malecka J, Chrostek G, Grilli M, Colombo L, Salmona M, Forloni G, Genazzani AA, Balducci C, Lim D. Genetic deletion of astrocytic calcineurin B1 prevents cognitive impairment and neuropathology development in acute and chronic mouse models of Alzheimer's disease. Glia. 2024 May;72(5):899-915. doi: 10.1002/glia.24509. Epub 2024 Jan 30. PMID: 38288580.
Dionisi M, Riva B, Delconti M, Meregalli C, Chiorazzi A, Canta A, Alberti P, Carozzi V, Pozzi E, Lim D, Genazzani AA, Distasi C, Cavaletti G. Inhibition of NHE1 transport activity and gene transcription in DRG neurons in oxaliplatin-induced painful peripheral neurotoxicity. Sci Rep. 2023 Mar 9;13(1):3991. doi: 10.1038/s41598-023-31095-9. PMID: 36894669; PMCID: PMC9998445.
Tapella L, Dematteis G, Genazzani AA, De Paola M, Lim D. Immortalized hippocampal astrocytes from 3xTg-AD mice, a new model to study disease-related astrocytic dysfunction: a comparative review. Neural Regen Res. 2023 Aug;18(8):1672-1678. doi: 10.4103/1673-5374.363192. PMID: 36751778; PMCID: PMC10154476.
Lim D, Tapella L, Dematteis G, Genazzani AA, Corazzari M, Verkhratsky A. The endoplasmic reticulum stress and unfolded protein response in Alzheimer's disease: A calcium dyshomeostasis perspective. Ageing Res Rev. 2023 Jun;87:101914. doi: 10.1016/j.arr.2023.101914. Epub 2023 Mar 21. PMID: 36948230.
Gong C, Bonfili L, Zheng Y, Cecarini V, Cuccioloni M, Angeletti M, Dematteis G, Tapella L, Genazzani AA, Lim D, Eleuteri AM. Immortalized Alzheimer's Disease Astrocytes: Characterization of Their Proteolytic Systems. Mol Neurobiol. 2023 May;60(5):2787-2800. doi: 10.1007/s12035-023-03231-z. Epub 2023 Feb 2. PMID: 36729287; PMCID: PMC10039838.
Lim D, Tapella L, Dematteis G, Talmon M, Genazzani AA. Calcineurin Signalling in Astrocytes: From Pathology to Physiology and Control of Neuronal Functions. Neurochem Res. 2023 Apr;48(4):1077-1090. doi: 10.1007/s11064-022-03744-4. Epub 2022 Sep 9. PMID: 36083398; PMCID: PMC10030417.
Villani S, Dematteis G, Tapella L, Gagliardi M, Lim D, Corazzari M, Aprile S, Del Grosso E. Quantification of the Chemical Chaperone 4-Phenylbutyric Acid (4-PBA) in Cell Culture Media via LC-HRMS: Applications in Fields of Neurodegeneration and Cancer. Pharmaceuticals (Basel). 2023 Feb 14;16(2):298. doi: 10.3390/ph16020298. PMID: 37259441; PMCID: PMC9960049.
Moccia F, Fiorio Pla A, Lim D, Lodola F, Gerbino A. Intracellular Ca2+ signalling: unexpected new roles for the usual suspect. Front Physiol. 2023 Jul 27;14:1210085. doi: 10.3389/fphys.2023.1210085. PMID: 37576340; PMCID: PMC10413985.
Tapella L, Dematteis G, Moro M, Pistolato B, Tonelli E, Vanella VV, Giustina D, La Forgia A, Restelli E, Barberis E, Cali T, Brini M, Villani S, Del Grosso E, Grilli M, Manfredi M, Corazzari M, Grolla AA, Genazzani AA, Lim D. Protein synthesis inhibition and loss of homeostatic functions in astrocytes from an Alzheimer's disease mouse model: a role for ER-mitochondria interaction. Cell Death Dis. 2022 Oct 18;13(10):878. doi: 10.1038/s41419-022-05324-4. PMID: 36257957; PMCID: PMC9579125.
Favero F, Barberis E, Gagliardi M, Espinoza S, Contu L, Gustincich S, Boccafoschi F, Borsotti C, Lim D, Rubino V, Mignone F, Pasolli E, Manfredi M, Zucchelli S, Corà D, Corazzari M. A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer's disease. PLoS One. 2022 Aug 24;17(8):e0273036. doi: 10.1371/journal.pone.0273036. PMID: 36001607; PMCID: PMC9401139.
Faris P, Rumolo A, Tapella L, Tanzi M, Metallo A, Conca F, Negri S, Lefkimmiatis K, Pedrazzoli P, Lim D, Montagna D, Moccia F. Store-Operated Ca2+ Entry Is Up-Regulated in Tumour-Infiltrating Lymphocytes from Metastatic Colorectal Cancer Patients. Cancers (Basel). 2022 Jul 7;14(14):3312. doi: 10.3390/cancers14143312. PMID: 35884372; PMCID: PMC9315763.
Dematteis G, Restelli E, Vanella VV, Manfredi M, Marengo E, Corazzari M, Genazzani AA, Chiesa R, Lim D, Tapella L. Calcineurin Controls Cellular Prion Protein Expression in Mouse Astrocytes. Cells. 2022 Feb 10;11(4):609. doi: 10.3390/cells11040609. PMID: 35203261; PMCID: PMC8870693.
Merlo S, Spampinato SF, Lim D. Molecular Aspects of Cellular Dysfunction in Alzheimer's Disease: The Need for a Holistic View of the Early Pathogenesis. Biomolecules. 2021 Dec 1;11(12):1807. doi: 10.3390/biom11121807. PMID: 34944450; PMCID: PMC8699369.
Tapella L, Dematteis G, Ruffinatti FA, Ponzoni L, Fiordaliso F, Corbelli A, Albanese E, Pistolato B, Pagano J, Barberis E, Marengo E, Balducci C, Forloni G, Verpelli C, Sala C, Distasi C, Sala M, Manfredi M, Genazzani AA, Lim D. Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures. Cell Calcium. 2021 Dec;100:102480. doi: 10.1016/j.ceca.2021.102480. Epub 2021 Sep 26. PMID: 34607180.
Lim D, Dematteis G, Tapella L, Genazzani AA, Calì T, Brini M, Verkhratsky A. Ca2+ handling at the mitochondria-ER contact sites in neurodegeneration. Cell Calcium. 2021 Sep;98:102453. doi: 10.1016/j.ceca.2021.102453. Epub 2021 Aug 5. PMID: 34399235.
Forcaia G, Formicola B, Terribile G, Negri S, Lim D, Biella G, Re F, Moccia F, Sancini G. Multifunctional Liposomes Modulate Purinergic Receptor-Induced Calcium Wave in Cerebral Microvascular Endothelial Cells and Astrocytes: New Insights for Alzheimer's disease. Mol Neurobiol. 2021 Jun;58(6):2824-2835. doi: 10.1007/s12035-021-02299-9. Epub 2021 Jan 29. PMID: 33511502; PMCID: PMC8128821.
Kriaučiūnaitė K, Kaušylė A, Pajarskienė J, Tunaitis V, Lim D, Verkhratsky A, Pivoriūnas A. Immortalised Hippocampal Astrocytes from 3xTG-AD Mice Fail to Support BBB Integrity In Vitro: Role of Extracellular Vesicles in Glial-Endothelial Communication. Cell Mol Neurobiol. 2021 Apr;41(3):551-562. doi: 10.1007/s10571-020-00871-w. Epub 2020 May 22. PMID: 32440709; PMCID: PMC11448679.
Astesana V, Faris P, Ferrari B, Siciliani S, Lim D, Biggiogera M, De Pascali SA, Fanizzi FP, Roda E, Moccia F, Bottone MG. [Pt(O,O'-acac)(γ-acac)(DMS)]: Alternative Strategies to Overcome Cisplatin-Induced Side Effects and Resistance in T98G Glioma Cells. Cell Mol Neurobiol. 2021 Apr;41(3):563-587. doi: 10.1007/s10571-020-00873-8. Epub 2020 May 19. Erratum in: Cell Mol Neurobiol. 2021 Apr;41(3):589. doi: 10.1007/s10571-020-00896-1. PMID: 32430779; PMCID: PMC11448674.
Lim D, Semyanov A, Genazzani A, Verkhratsky A. Calcium signaling in neuroglia. Int Rev Cell Mol Biol. 2021;362:1-53. doi: 10.1016/bs.ircmb.2021.01.003. Epub 2021 Apr 10. PMID: 34253292.
S. Lomazzi, M. Caccia, C. Distasi, M. Dionisi, D. Lim, A. Martemiyanov, L. Nardo, F.A. Ruffinatti, R. Santoro. Assessment of the potential of SiPM-based systems for bioluminescence detection. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2020. Vol 979:164493, ISSN 0168-9002, https://doi.org/10.1016/j.nima.2020.164493.
Dionisi M, Ruffinatti FA, Riva B, Lim D, Canta A, Meregalli C, Fumagalli G, Monza L, Ferrer-Montiel A, Fernandez-Carvajal A, Cavaletti G, Genazzani AA, Distasi C. Early Stimulation of TREK Channel Transcription and Activity Induced by Oxaliplatin-Dependent Cytosolic Acidification. Int J Mol Sci. 2020 Sep 28;21(19):7164. doi: 10.3390/ijms21197164. PMID: 32998392; PMCID: PMC7584002.
Ruffinatti FA, Lomazzi S, Nardo L, Santoro R, Martemiyanov A, Dionisi M, Tapella L, Genazzani AA, Lim D, Distasi C, Caccia M. Assessment of a Silicon-Photomultiplier-Based Platform for the Measurement of Intracellular Calcium Dynamics with Targeted Aequorin. ACS Sens. 2020 Aug 28;5(8):2388-2397. doi: 10.1021/acssensors.0c00277. Epub 2020 Aug 5. PMID: 32701269; PMCID: PMC8009593.
Dematteis G, Vydmantaitė G, Ruffinatti FA, Chahin M, Farruggio S, Barberis E, Ferrari E, Marengo E, Distasi C, Morkūnienė R, Genazzani AA, Grilli M, Grossini E, Corazzari M, Manfredi M, Lim D, Jekabsone A, Tapella L. Proteomic analysis links alterations of bioenergetics, mitochondria-ER interactions and proteostasis in hippocampal astrocytes from 3xTg-AD mice. Cell Death Dis. 2020 Aug 18;11(8):645. doi: 10.1038/s41419-020-02911-1. PMID: 32811809; PMCID: PMC7434916.
Dematteis G, Restelli E, Chiesa R, Aronica E, Genazzani AA, Lim D, Tapella L. Calcineurin Controls Expression of EAAT1/GLAST in Mouse and Human Cultured Astrocytes through Dynamic Regulation of Protein Synthesis and Degradation. Int J Mol Sci. 2020 Mar 23;21(6):2213. doi: 10.3390/ijms21062213. PMID: 32210081; PMCID: PMC7139922.
Tapella L, Soda T, Mapelli L, Bortolotto V, Bondi H, Ruffinatti FA, Dematteis G, Stevano A, Dionisi M, Ummarino S, Di Ruscio A, Distasi C, Grilli M, Genazzani AA, D'Angelo E, Moccia F, Lim D. Deletion of calcineurin from GFAP-expressing astrocytes impairs excitability of cerebellar and hippocampal neurons through astroglial Na+ /K+ ATPase. Glia. 2020 Mar;68(3):543-560. doi: 10.1002/glia.23737. Epub 2019 Oct 18. PMID: 31626368.
Torretta S, Colombo G, Travelli C, Boumya S, Lim D, Genazzani AA, Grolla AA. The Cytokine Nicotinamide Phosphoribosyltransferase (eNAMPT; PBEF; Visfatin) Acts as a Natural Antagonist of C-C Chemokine Receptor Type 5 (CCR5). Cells. 2020 Feb 21;9(2):496. doi: 10.3390/cells9020496. PMID: 32098202; PMCID: PMC7072806.
Di Buduo CA, Abbonante V, Marty C, Moccia F, Rumi E, Pietra D, Soprano PM, Lim D, Cattaneo D, Iurlo A, Gianelli U, Barosi G, Rosti V, Plo I, Cazzola M, Balduini A. Defective interaction of mutant calreticulin and SOCE in megakaryocytes from patients with myeloproliferative neoplasms. Blood. 2020 Jan 9;135(2):133-144. doi: 10.1182/blood.2019001103. PMID: 31697806; PMCID: PMC6952826.
Lodola F, Rosti V, Tullii G, Desii A, Tapella L, Catarsi P, Lim D, Moccia F, Antognazza MR. Conjugated polymers optically regulate the fate of endothelial colony-forming cells. Sci Adv. 2019 Sep 27;5(9):eaav4620. doi: 10.1126/sciadv.aav4620. PMID: 31598549; PMCID: PMC6764832.
Talmon M, Rossi S, Lim D, Pollastro F, Palattella G, Ruffinatti FA, Marotta P, Boldorini R, Genazzani AA, Fresu LG. Absinthin, an agonist of the bitter taste receptor hTAS2R46, uncovers an ER-to-mitochondria Ca2+-shuttling event. J Biol Chem. 2019 Aug 16;294(33):12472-12482. doi: 10.1074/jbc.RA119.007763. Epub 2019 Jun 27. PMID: 31248983; PMCID: PMC6699840.
Faris P, Pellavio G, Ferulli F, Di Nezza F, Shekha M, Lim D, Maestri M, Guerra G, Ambrosone L, Pedrazzoli P, Laforenza U, Montagna D, Moccia F. Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Induces Intracellular Ca2+ Release through the Two-Pore Channel TPC1 in Metastatic Colorectal Cancer Cells. Cancers (Basel). 2019 Apr 15;11(4):542. doi: 10.3390/cancers11040542. PMID: 30991693; PMCID: PMC6521149.
Zuccolo E, Kheder DA, Lim D, Perna A, Nezza FD, Botta L, Scarpellino G, Negri S, Martinotti S, Soda T, Forcaia G, Riboni L, Ranzato E, Sancini G, Ambrosone L, D'Angelo E, Guerra G, Moccia F. Glutamate triggers intracellular Ca2+ oscillations and nitric oxide release by inducing NAADP- and InsP3 -dependent Ca2+ release in mouse brain endothelial cells. J Cell Physiol. 2019 Apr;234(4):3538-3554. doi: 10.1002/jcp.26953. Epub 2018 Nov 19. PMID: 30451297.
Rocchio F, Tapella L, Manfredi M, Chisari M, Ronco F, Ruffinatti FA, Conte E, Canonico PL, Sortino MA, Grilli M, Marengo E, Genazzani AA, Lim D. Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer's disease mouse model. Cell Death Dis. 2019 Jan 10;10(1):24. doi: 10.1038/s41419-018-1264-8. Erratum in: Cell Death Dis. 2020 Apr 16;11(4):236. doi: 10.1038/s41419-020-2451-y. PMID: 30631041; PMCID: PMC6328590.